B Cell Proliferation Assay for Autoimmune Disease Drug Activity

Vivia’s anti-proliferative assay provides the best conditions for patient-derived B cells ex vivo culture, allowing a wide variety of therapeutic compounds screening.

Proliferative B cells are crucial in autoimmune diseases through autoantibody production, antigen presentation, cytokine secretion, and ectopic germinal center formation. Inhibiting their proliferation limits these effects and balances regulatory and autoreactive B cells, essential for immune homeostasis. Therapies that inhibit B cell activity, like anti-CD20 antibodies, JAK, and mTOR inhibitors improve the management of rheumatoid arthritis, lupus, and multiple sclerosis.

The combination of CpG (B-class ODN2006) plus human stromal cell line HS5 (doi: 10.18632/oncotarget.25419) prevents patient-derived spontaneous cell death, promotes the proliferation of B cells, and immunoglobulin secretion.

It makes our assay the ideal platform to evaluate B cell response to stimuli.

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Vivia’s B cell ex vivo assays can help your new autoimmune diseases therapy development.

Our B cell Proliferative can be used to: