Bispecific Antibodies Testing
The Tumor Microenvironment (TME) has a key role in Solid Tumor Therapy Screening. The 3D TME-aligned model recapitulates original tumor microenvironment and promotes naïve behavior of tumor and immune cells. Once embedded in this native-like matrix, T-cells and tumor cells interact through immunological synapses potentialized by Bispecific (or multispecific) antibodies. The cell retrieval at the end of treatment allows full mode of action characterization by FCM and description of genetic basis of resistance.
Tumorcell
T Cells Tils Solid Tumor
Tme Aligned 3d
Tme Tumor Media

Antibody F2488C
Cytotoxic Compund Solid Tumor
Single Tumorcell

Tumor Cells

Single Hmscfactors

hMSC factors

T Cells TILs

T-Cells / TILs

Plate Tumor Solid

Cells Source

Naïve-like Tumor Microenvironment:
TME-aligned 3D Model

Cells Retrieval
& FCM Readout

Ex-vivo Bispecific Ab Screening:
TME-aligned 3D IO Model

Graf Bispecific
Cells Source
Tumorcell
T Cells Tils Solid Tumor
Tme Aligned 3d
Tme Tumor Media
Naïve-like Tumor Microenvironment: TME-aligned 3D Model

Antibody F2488C
Cytotoxic Compund Solid Tumor
Single Tumorcell

Tumor Cells

Single Hmscfactors

hMSC factors

T Cells TILs

T-Cells / TILs

Cells Retrieval
& FCM Readout
Plate Tumor Solid
Ex-vivo Bispecific Ab Screening:
TME-aligned 3D IO Model
Graf Bispecific