Cytotoxic Compounds Testing
The Tumor Microenvironment (TME) has a key role in Solid Tumor Therapy Screening. The 3D TME-aligned model recapitulates original tumor microenvironment and promotes naïve behavior of tumor cells. Once re-educated in this native-like matrix, the tumor cells respond in a superiorly faithful manner to cytotoxic compounds. The cell retrieval at the end of treatment allows full mode of action characterization by FCM and description of genetic basis of resistance.
- Tumor cells
- TME-aligned 3D matrix
- TME-aligned tumor media
Cytotoxic Compounds
Tumor Cells
T-Cells Activation
- Inflammatory TME
- Acidic pH / Low glucose
- Reliable Drug Response
- Cells Retrieval
- Ki67 / EdU
- Molecular bases of resistance
Tumor Cell Lines
or Patient Samples
Naïve-like Tumor Microenvironment:
TME-aligned 3D Model
Cells Retrieval
& FCM Readout
Ex-vivo Drug Screening:
TME-aligned 3D Model
- Up to 7 colour markers – full cell profiling
- Good statistics & reproducibility
- Low time consuming
- FACS sorting functionally relevant cells
- Molecular on all or cell subsets
- MoA, signaling
- Epigenetic readouts
Tumor Cell Lines
or Patient Samples
or Patient Samples
- Tumor cells
- TME-aligned 3D matrix
- TME-aligned tumor media
Naïve-like Tumor Microenvironment:
TME-aligned 3D Model
Cytotoxic Compounds
Tumor Cells
T-Cells Activation
- Inflammatory TME
- Acidic pH / Low glucose
- Reliable Drug Response
Cells Retrieval
& FCM Readout
& FCM Readout
- Cells Retrieval
- Ki67 / EdU
- Molecular bases of resistance
Ex-vivo Drug Screening:
TME-aligned 3D Model
TME-aligned 3D Model
- Up to 7 colour markers – full cell profiling
- Good statistics & reproducibility
- Low time consuming
- FACS sorting functionally relevant cells
- Molecular on all or cell subsets
- MoA, signaling
- Epigenetic readouts
