Cytotoxic Compounds Testing
The Tumor Microenvironment (TME) has a key role in Solid Tumor Therapy Screening. The 3D TME-aligned model recapitulates original tumor microenvironment and promotes naïve behavior of tumor cells. Once re-educated in this native-like matrix, the tumor cells respond in a superiorly faithful manner to cytotoxic compounds. The cell retrieval at the end of treatment allows full mode of action characterization by FCM and description of genetic basis of resistance.
Tumorcell
Tme Aligned 3d
Tme Tumor Media

Cytotoxic Compund Solid Tumor
Single Tumorcell

Tumor Cells

Single Hmscfactors

T-Cells Activation

Plate Tumor Solid

Tumor Cell Lines
or Patient Samples

Naïve-like Tumor Microenvironment:
TME-aligned 3D Model

Cells Retrieval
& FCM Readout

Ex-vivo Drug Screening:
TME-aligned 3D Model

Tumor Cell Lines
or Patient Samples
Tumorcell
Tme Aligned 3d
Tme Tumor Media
Naïve-like Tumor Microenvironment: TME-aligned 3D Model

Cytotoxic Compund Solid Tumor
Single Tumorcell

Tumor Cells

Single Hmscfactors

T-Cells Activation

Cells Retrieval
& FCM Readout
Plate Tumor Solid
Ex-vivo Drug Screening:
TME-aligned 3D Model