Compound Profiling by Flow Cytometry
Inmunophenotyping and Receptor expression​
Inmunophenotyping and Receptor expression​
Pharmacological Effects from Ex Vivo Assays
Pharmacological Effects from Ex Vivo Assays
- Analysis of pharmacological cytotoxic and antiproliferative effects of single drugs over cell populations and subpopulations identified by flow cytometry
- Dose-response curve fitting and drug effect normalization
- Pharmacodynamic parameters estimation. Area under the curve
- Categorical analysis according to different variables: experimental conditions, subpopulations identified by different markers...
- Comparative analysis among drugs tested under same experimental conditions

- Characterization of population pharmacological effects of drugs through Pharmacodynamic Mixed-Effects Non-linear population models using NONMEM® software. Estimation of population typical parameters and associated inter-patient variability together with model quality parameters and errors estimations.
- Estimation of synergy in the pharmacological effects (cytotoxic or antiproliferative) observed in combination experiments using two drugs
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Empirical estimation using Combination Index
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Color maps for estimation of optimal synergistic dose-ratios
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Modeling using Interaction Surface approach. 3D Surface plots