Categorized analysis of population and subtypes identified by flow cytometry
Dot-plots and histograms from cytometry analysis
Pharmacological Effects from Ex Vivo Assays
Analysis of pharmacological cytotoxic and antiproliferative effects of single drugs over cell populations and subpopulations identified by flow cytometry
Dose-response curve fitting and drug effect normalization
Pharmacodynamic parameters estimation. Area under the curve
Categorical analysis according to different variables: experimental conditions, subpopulations identified by different markers...
Comparative analysis among drugs tested under same experimental conditions
Characterization of population pharmacological effects of drugs through Pharmacodynamic Mixed-Effects Non-linear population models using NONMEM® software. Estimation of population typical parameters and associated inter-patient variability together with model quality parameters and errors estimations.
Estimation of synergy in the pharmacological effects (cytotoxic or antiproliferative) observed in combination experiments using two drugs
Empirical estimation using Combination Index
Color maps for estimation of optimal synergistic dose-ratios
Modeling using Interaction Surface approach. 3D Surface plots