Innovative Drug Interaction Studies
Drug combinations are critical in many diseases, including cancer. Synergistic drugs allow the use of lower doses in the treatment and therefore the adverse reactions would probably be reduced.
Vivia has developed a workflow including different methods like traditional dose dependant indexes, surface modeling¹ (Greco et al., 1995) and the new MuSyC²,³ algorithm to perform a complete drug interaction study.
Drug interaction study phases
Interactive Demo - Drug interaction 3D surface
- Greco, W.R., Bravo, G., and Parsons, J.C. (1995). The search for synergy: a critical review from a response surface perspective. Pharmacol. Rev. 47, 331–385.
- Meyer, C.T., Wooten, D.J., Paudel, B.B., Bauer, J., Hardeman, K.N., Westover, D., Lovly, C.M., Harris, L.A., Tyson, D.R., and Quaranta, V. (2019). Quantifying drug combination synergy along potency and efficacy axes. Cell Syst. 8, 97–108.e16. https://doi.org/10.1016/j.cels.2019.01.003
- Wooten, David J, and Albert, Réka. synergy – A Python library for calculating, analyzing, and visualizing drug combination synergy. (2020) Bioinformatics. https://doi.org/10.1093/bioinformatics/btaa826