Migration and Invasion Assays
The Tumor Microenvironment (TME) has a key role in Solid Tumor Therapy Screening. TME-aligned model recapitulates original tumor microenvironment and promotes naïve behavior of tumor cells. Once embedded in this native-like matrix, tumor cells can migrate and invade, crucial steps for solid tumor metastasis in vivo. This assay enables evaluation of drugs that affects migratory capacity of tumor cells. The cell retrieval at the end of invasive process allows full mode of action characterization by FCM.

Therapy

Migration Therapy

Stimulus-directed
Migration

Migration Stimulus

Cell
Retrieval

Migration Cell Retrieval
Plate Tumor Solid

Cells Source

Naïve-like Tumor Microenvironment:
TME-aligned 3D Model

Cells Retrieval
& FCM Readout

Ex-vivo Bispecific Ab Screening:
TME-aligned 3D IO Model

Cells Source

Therapy

Migration Therapy
Naïve-like Tumor Microenvironment: TME-aligned 3D Model

Stimulus-directed
Migration

Migration Stimulus

Cell
Retrieval

Migration Cell Retrieval
Cells Retrieval
& FCM Readout
Plate Tumor Solid
Ex-vivo Migration & Invasion Assays:
TME-aligned Model