Select AML samples with desired molecular profiles
for your ex vivo experiments
for your ex vivo experiments
Vivia Biotech can combine ex vivo activity with molecular data generated by NGS to better understand your drug activity in real AML patient samples
NGS panel covers the most relevant genetic alteration for AML patients
Functional Data Correlates with Molecular Genotypes
Key Highlights
- At Vivia we have a collection of frozen AML samples with molecular information
- Imagine having previous molecular information in real AML patient samples to design your ex vivo assays and be able to compare the tumor response with genetic information.
- Focus efforts on the most interesting samples, those with actionable biomarkers by targeted treatments or resistant to particular drugs.
- Go further exploring drug specificity by combining ex vivo and genetic data: correlations between observed ex vivo behavior and genetic biomarkers.
- Convert ex vivo functional response such as sensitive vs resistant cells to NGS genomic markers of drug response such as drug sensitive vs resistant NGS markers, that you can add to your NGS panel for your clinical trial.
- We provide customized assays to explore the mechanisms of action of your drug of interest.
- Evaluate investigational agents in preclinical and clinical studies and correlate with molecular info.
- Find out novel biomarkers to be used in preclinical and clinical studies.
Published data
AML drug response profile, mutational profile and clinical features connection
Mutational status modified pharmacological response of AML SoC drugs
Overall Survival Curves: molecular genotypes in combination with
ex vivo multi-resistant profile status at diagnosis