Targeted Drugs Testing
The Tumor Microenvironment (TME) has a key role in Solid Tumor Therapy Screening. The 3D TME-aligned model recapitulates original tumor microenvironment and promotes naïve behavior of tumor cells. Once re-educated in this Tumor-Type Custom Model, the tumor cells respond in a superiorly faithful manner to Targeted Therapy Agents. The cell retrieval at the end of treatment allows full mode of action characterization by FCM and description of genetic basis of resistance.
Tumorcell
  • Tumor cells
Tme Aligned 3d
  • TME-aligned 3D matrix
Tme Tumor Media
  • TME-aligned tumor media

Cytotoxic Compund Solid Tumor
Single Tumorcell

Tumor Cells

Single Hmscfactors

hMSC factors

  • Inflammatory TME
  • Acidic pH / Low glucose
  • Reliable Drug Response
Plate Tumor Solid
  • Cells Retrieval
  • Ki67 / EdU
  • Molecular bases of resistance

Tumor Cell Lines
or Patient Samples

Naïve-like Tumor Microenvironment:
TME-aligned 3D Model

Cells Retrieval
& FCM Readout

Ex-vivo Drug Screening:
TME-aligned 3D Model

  • Up to 7 colour markers – full cell profiling
  • Good statistics & reproducibility
  • Low time consuming
  • FACS sorting functionally relevant cells
  • Molecular on all or cell subsets
  • MoA, signaling
  • Epigenetic readouts
Tumor Cell Lines
or Patient Samples
Tumorcell
  • Tumor cells
Tme Aligned 3d
  • TME-aligned 3D matrix
Tme Tumor Media
  • TME-aligned tumor media
Naïve-like Tumor Microenvironment: TME-aligned 3D Model

Cytotoxic Compund Solid Tumor
Single Tumorcell

Tumor Cells

Single Hmscfactors

T-Cells Activation

  • Inflammatory TME
  • Acidic pH / Low glucose
  • Reliable Drug Response
Cells Retrieval
& FCM Readout
Plate Tumor Solid
  • Cells Retrieval
  • Ki67 / EdU
  • Molecular bases of resistance
Ex-vivo Drug Screening:
TME-aligned 3D Model
  • Up to 7 colour markers – full cell profiling
  • Good statistics & reproducibility
  • Low time consuming
  • FACS sorting functionally relevant cells
  • Molecular on all or cell subsets
  • MoA, signaling
  • Epigenetic readouts