TME Immunosuppression Assay: Enhancing Immuno-Oncology Development

The tumor microenvironment (TME) comprises of distinct cell types, each of which can assume a variety of phenotypes defined by the expression of multiple proteins. It contains tumor, stromal and several types of immune cells, irrigated by an altered vascular system and embedded in a dense extracellular matrix, which compromises its oxygen levels.

Vivia’s TME-aligned model mimics TME changes providing a hypoglycemic, acidic or matrix embedded environment, and a plethora of inflammatory signals obtained from stimulated human mesenchymal stem cells (hMSC).
Assay

The hMSCs secrete soluble molecules which suppress the activity and proliferation of immune cells, including T and B lymphocytes, NK cells, and dendritic cells, as well as activate T regulatory cells (Tregs).

Lower T Cell Activation
Wugen Data
Vivia’s TME-aligned assays provide a more immunosuppressive environment and are designed to fully explore your drug or cell product potency

Our TME-aligned immunosuppressive in vitro assay can be used to:

  • Activate environment-dependent antibodies
  • Evaluate T Cell Engagers or Immune Checkpoint Inhibitors immune suppression on effector cells in challenging conditions (pH, glucose, extracellular matrix stiffness, immunosuppressive factors)
  • Evaluate the potency of cell therapy products as TILs, CART or NK cells
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