Antibody-dependent Cellular cytotoxicity (ADCC)
The Antibody-Dependent Cellular Cytotoxicity (ADCC) Assay incorporates real Effector to Target ratios (NK Cells: Leukemic Cells) to capture the activity of these monoclonal antibodies mediated by cells displaying Fc receptors, such as NK cells and macrophages, evaluating their depletion results based on the quantification of live cells. Initial target quantification is evaluated by Flow Cytometry to correlate with the ex vivo activity.
- AML
- CLL
- MM
- Red Blood Cells
- Platelets
- AML / CLL / MM Leukemic Cells
- Natural Killer Cells
- Others
Antibodies Therapy
Natural Killer Cells Activation
Hematological
Sample
Native Cell
Population
Antibody Incubation
NK Cells Activation
Cells Retrieval &
FCM Readout
CDC Assay:
Native Environment
Hematological
Sample
Sample
- AML
- CLL
- MM
Native Cell
Population
- Red Blood Cells
- Platelets
- AML / CLL / MM Leukemic Cells
- Natural Killer Cells
- Others
Antibody Incubation
NK Cells Activation
Antibodies
Therapy
Therapy
Natural Killer Cells Activation
Cells Retrieval &
FCM Readout
CDC Assay:
Native Environment
Native Environment