Complement-dependent cytotoxicity (CDC)
The Complement-Dependent Cytotoxicity (CDC) Assay incorporates Human Serum or Autologous plasma to capture the activity of these monoclonal antibodies by evaluating their depletion results based on the quantification of live cells. Initial target quantification is evaluated by Flow Cytometry to correlate with the ex vivo activity.

- AML
- CLL
- MM

- Red Blood Cells
- Platelets
- Neutrophils
- AML / CLL / MM Leukemic Cells
- Lymphocytes
- Others
Drug Therapy
Human
Serum



Hematological
Sample
Native Cell
Population
Drug Incubation
+ humanSerum
Cells Retrieval &
FCM Readout
CDC Assay:
Native Environment

Hematological
Sample
Sample

- AML
- CLL
- MM
Native Cell
Population

- Red Blood Cells
- Platelets
- Neutrophils
- AML / CLL / MM Leukemic Cells
- Lymphocytes
- Others
Drug Incubation
+ humanSerum
Drug Therapy
Human
Serum


Cells Retrieval &
FCM Readout

CDC Assay:
Native Environment
Native Environment
