Immunoglobulin Secretion
Measuring immunoglobulin secretion provides a functional readout of B-cell activity, offering insight into their role in autoantibody production and immune dysregulation. This approach is particularly valuable for evaluating the effect of therapeutic agents on antibody-producing cells and for understanding mechanisms involved in disease persistence and treatment resistance.
Drug-induced changes in immunoglobulin secretion reveal functional differences between B cells from healthy donors and autoimmune patients. Monitoring the secretion of different antibody classes provides insight into how therapies affect both the magnitude and quality of B-cell responses in a disease-relevant context.