T-Cell Polyclonal Activation
Polyclonal stimulation provides a robust model to assess T-cell functionality and drug effects under standardized activation conditions. This assay is especially useful to explore T-cell behavior in autoimmune settings, including activation, exhaustion, cytokine release, and effector function.
Polyclonal activation under controlled ex vivo conditions allows for a comprehensive functional assessment of T cells derived from healthy or autoimmune donors. Readouts include viability, CD4/CD8 ratio, activation markers, cytokine production, exhaustion profiles, and effector functions, offering a multidimensional view of how therapeutic agents modulate T-cell responses.
